Improve Drug Delivery for Brain Tumor Patients

Overcoming the physical challenges limiting drug delivery for brain tumor patients has the potential to dramatically improve therapeutic efficacy for many agents, ranging from traditional chemotherapies to larger antibody-drug conjugates and cellular based therapies. Focused ultrasound mediated blood-brain barrier disruption is an attractive strategy to improve drug delivery, and our group is exploring preclinical and clinical strategies to enhance drug delivery.  I am designing a prototype for intra-operative focused ultrasound to specifically open the blood-brain barrier in regions of residual glioblastoma cells after a tumor resection.